On our chemistry line (c501), we run two control levels at 05:30 and occasionally see a lone Westgard 1-3s on glucose right after a reagent lot change; do you lock out and troubleshoot immediately, or repeat once before holding patient samples? I’m updating our SOP to balance turnaround time with data integrity and want to hear what you enforce on the bench.
We allow one repeat with a fresh QC aliquot and re‑mixed reagent pack; if the ‘lone 1-3s right after a lot change’ repeats, we lock out, run lot-to-lot or a third QC level, and verify calibration/pack age before releasing patients. If it corrects, we proceed but flag the run for review and do quick glucose deltas — measure twice, cut once. Do you have a third QC level or a backup hexokinase method to confirm?
On our c501, the one-off 1-3s mostly disappeared when we invert the new cPack about 10x, run Reagent Prime, and let it sit 10–15 min before QC; if it still trips, I do one rerun with a fresh aliquot while auto-ver is paused. “right after a lot change” — I treat that as a mixing/temp artifact first; do you let the pack equilibrate before running glucose?