Has anyone moved from high-throughput core chemistry to a tox LC-MS/MS bench recently? I’m on nights running about 900 specimens on a Cobas 8000, enforcing Westgard multirules and HIL checks, and I’m trying to gauge what hiring managers want to see — hands-on with method validation (carryover, matrix effects, LoD/LoQ), preventive maintenance documentation, or just basic sample prep — before I make the jump.
Coming off nights on a Cobas 8000, the one thing that got me traction was bringing a one‑page LC‑MS/MS validation write‑up — ‘carryover, matrix effects, LoD/LoQ’ — from a small deuterated‑ISTD method I built on borrowed time, with raw data and PM logs attached. @OP, do you have access to a bench to run a quick post‑extraction spike so you can show matrix factor and carryover data? If not, use this AACC summary as a template and mirror the format on a Cobas dilution/linearity experiment and tie your Westgard/HIL calls to acceptance criteria: https://www.aacc.org/cln/cln-stat/2018/august/23/clinical-laboratory-lc-ms-method-validation.
We moved pre-op verifications remote by having sanitation upload three annotated photos per line plus a 30‑sec ATP/swab dashboard to Teams, then QA e‑signs by 5:05 a.m. under a simple ‘no‑ship without sign‑off’ SOP; works great unless Wi‑Fi hiccups, so we keep a paper timestamp fallback — think pit stop, not extra shift. @Marisol, have you tried locking file names to line‑date‑lot to keep auditors happy?